Individual study plan
Bedside assessment of Microvascular Dysfunction
Method evaluation in clinical studies
Disposition
Introduction and Background : Introduction to the topic, research objectives
Research plan and Methodology : Study designs, methods and analysis
Timeline and Milestones : Project timeline with key milestones
Resources and Support : Overview of resources and support
Discussion and Feedback : Opportunity for audience feedback
Introduction and Background
Relevance
Introduction and Background
Relevance
Key Areas : Cardiovascular disease, diabetes, heart failure, sepsis
Clinical Implications
Early Detection and Prevention : Monitoring microvascular function helps identify patients at high risk, enabling early intervention and preventive measures.
Disease Progression and Treatment Monitoring : Microvascular assessment provides a window into disease activity, aiding in the evaluation of treatment effectiveness.
Goal-Directed Therapy : Insights into microvascular health support goal-directed therapies, optimizing treatment plans tailored to individual needs.
Introduction and Background
Problem
Current methods
Capillary refill time Subjectivity, variability, sens/spec, non-quantifiable*
Coronary angiography Invasive, cumbersome, resource intensive, organ specific
Stress Cardiac MRT Cumbersome, resource intensive, organ specific
Biomarkers Analysis time, interpretation, resource intensive
Introduction and Background
Problem
Future methods - what is needed?
Quantitative Precision and comparison
Non-invasive Risk and discomfort
Low variability and High sensitivity Consistency and precision
Rapid and ease of use Clinical convenience
Organ-agnostic Systemic dysfunction
Cost-effective Iterative usage and goal-directed
Research Plan and Methodology
The CapriS Study, Capillary Dysfunction in Sepsis
Patients with severe sepsis or septic shock
Rapid microvascular decompensation
The MIND Study, Microangiopathy in Diabetes
Patients with type 1 diabetes, with and without clinical microangiopathy
Chronic microvascular deterioration
SCAPIS2Spectrum, Microcirculation Substudy
Patients with high risk of cardiac microangiopathy
Microangiopathy in different populations
Timeline and Milestones
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section Studies
Microangiopathy IN Diabetes(MIND) : 2024-01, 2027-06
Capillary dysfunction in Sepsis(CapriS) : 2024-01, 2028-06
SCAPIS2Spectrum - Microcirculation substudy : 2024-03, 2029-01
section Conferences
European Society on Microcirculation :milestone 2025-05, 2025-06
ISICEM :milestone 2026-03, 2026-04
European Society on Microcirculation :milestone 2027-04, 2027-05
section Journal clubs
IMA-Journal Clubs : 2024-08, 2029-05
section Milestones
Start date :milestone, 2024-08, 2024-08
Half-Time Control :milestone, 2026-08, 2026-08
Dissertation Defense :milestone, crit, 2029-05, 2029-05
Timeline and Milestones
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section Mandatory courses
Introduction to Doctoral Education at KI : 2024-10, 2024-12
Basic Laboratory Safety : 2024-12, 2025-01
Medical Research Ethics : 2025-01, 2025-02
Introductory course in clinical studies : 2025-02, 2025-03
Basic Course in Medical Statistics : 2025-03, 2025-04
Present your Research! : 2025-10, 2025-11
Quality Assurance of Clinical Research : 2025-10, 2025-11
section Project specific courses
Statistical Methods with R : 2024-09, 2024-12
Programing in Python : 2024-08, 2024-11
Endothelial Cell Function[...] : 2026-02, 2026-03
Intermediate Medical Statistics : 2026-03, 2026-04
Cellular Signalling : 2026-04, 2026-05
section Milestones
Start date :milestone, 2024-08, 2024-08
Half-Time Control :milestone, 2026-08, 2026-08
Dissertation Defense :milestone, crit, 2029-05, 2029-05
Resources and Support
Supervisor : Sara Tehrani, MD, PhD, MICU specialist
Co-Supervisor : Maria Cronhjort, MD, PhD, anesthesiologist and ICU specialist
Courses and Education
KFC-Statistician
Research seminars
Challanges and Risk Management
Large Scale Studies
Participant Scheduling
Automatic scheduling system
Data Collection
Partially automatic data collection and integrity system
Data Analysis Phase
Well-defined analytic aims
Specific courses
Discussion and Feedback